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DNA isn’t the simple, loose double-helix you might see in a biology textbook, so isolating single strands of it can be next to impossible. But with some simple tricks of physics, scientists came up with a special type of tweezers that can unzip DNA!
Hosted by: Rose Bear Don't Walk
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Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever:
Chris Peters, Matt Curls, Kevin Bealer, Jeffrey Mckishen, Jacob, Christopher R Boucher, Nazara, Jason A Saslow, charles george, Christoph Schwanke, Ash, Bryan Cloer, Silas Emrys, Eric Jensen, Adam Brainard, Piya Shedden, Jeremy Mysliwiec, Alex Hackman, GrowingViolet, Sam Lutfi, Alisa Sherbow, Dr. Melvin Sanicas, Melida Williams, Tom Mosner
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Sources:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00453-6
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-11-5-288
https://www.cambridge.org/core/books/optical-tweezers/introduction/DB937BE06C9CCA79FDA01F43BB312AE5
https://www.pnas.org/content/94/10/4853
https://www.nobelprize.org/uploads/2018/10/ashkin-lecture.pdf
https://www.annualreviews.org/doi/10.1146/annurev.bi.49.070180.005343
https://pubs.acs.org/doi/full/10.1021/cr4003006
https://www.nature.com/articles/s43586-021-00021-6
https://www.sciencedirect.com/science/article/pii/S0092867418315113
Image Sources:
https://www.istockphoto.com/photo/three-tweezers-tweezers-on-a-white-background-gm1262858821-369561418
https://www.storyblocks.com/video/stock/a-young-man-plucking-his-eyebrows-with-tweezers-styling-eyebrows-macro-r05jp9o1fja32nmvz
https://www.storyblocks.com/video/stock/seamless-looping-animation-of-rotating-dna-strands-e1hwm_0cgiks0m37h
https://commons.wikimedia.org/wiki/File:Nucleosome_1KX5_2.png
https://www.storyblocks.com/video/stock/animation-of-genetic-dna-loop-able-4k-rxfbx2wcgizuoo76d
https://www.storyblocks.com/video/stock/floating-cells-multiplying-red-version-lxo-vwt
https://www.istockphoto.com/photo/chromosome-isolated-on-white-background-with-depth-of-field-effect-gm584244506-100036213
https://commons.wikimedia.org/wiki/File:Nucleosome_organization.png
https://commons.wikimedia.org/wiki/File:Nucleosome.png
https://commons.wikimedia.org/wiki/File:Basic_units_of_chromatin_structure.svg
https://commons.wikimedia.org/wiki/File:Sail-Force1.gif
https://commons.wikimedia.org/wiki/File:World%27s_first_laser_out_of_case.jpg
https://commons.wikimedia.org/wiki/File:Military_laser_experiment.jpg
https://commons.wikimedia.org/wiki/File:Femtomolar_Optical_Tweezers_(5881942888).jpg
https://www.istockphoto.com/photo/chromatin-strand-and-isolated-nucleosome-dna-histones-gm1169905740-323575931
https://commons.wikimedia.org/wiki/File:1aoi_nucleosome_rib_round.tif
https://commons.wikimedia.org/wiki/File:Stylized_DNA.png
https://www.storyblocks.com/video/stock/lamp-and-the-books-in-library-2-rag585s9rk2i80i6s
https://commons.wikimedia.org/wiki/File:Table_chamber_GWMorley.jpg
https://www.istockphoto.com/photo/3d-illustration-protein-or-enzyme-gm1138925640-304251159
https://www.storyblocks.com/video/stock/dna-sequencing-the-bases-of-a-fragment-of-dna-abstract-background-skx-uxydpkgvmnshp
DNA isn’t the simple, loose double-helix you might see in a biology textbook, so isolating single strands of it can be next to impossible. But with some simple tricks of physics, scientists came up with a special type of tweezers that can unzip DNA!
Hosted by: Rose Bear Don't Walk
SciShow is on TikTok! Check us out at https://www.tiktok.com/@scishow
----------
Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow
----------
Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever:
Chris Peters, Matt Curls, Kevin Bealer, Jeffrey Mckishen, Jacob, Christopher R Boucher, Nazara, Jason A Saslow, charles george, Christoph Schwanke, Ash, Bryan Cloer, Silas Emrys, Eric Jensen, Adam Brainard, Piya Shedden, Jeremy Mysliwiec, Alex Hackman, GrowingViolet, Sam Lutfi, Alisa Sherbow, Dr. Melvin Sanicas, Melida Williams, Tom Mosner
----------
Looking for SciShow elsewhere on the internet?
SciShow Tangents Podcast: http://www.scishowtangents.org
Facebook: http://www.facebook.com/scishow
Twitter: http://www.twitter.com/scishow
Instagram: http://instagram.com/thescishow
----------
Sources:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00453-6
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-11-5-288
https://www.cambridge.org/core/books/optical-tweezers/introduction/DB937BE06C9CCA79FDA01F43BB312AE5
https://www.pnas.org/content/94/10/4853
https://www.nobelprize.org/uploads/2018/10/ashkin-lecture.pdf
https://www.annualreviews.org/doi/10.1146/annurev.bi.49.070180.005343
https://pubs.acs.org/doi/full/10.1021/cr4003006
https://www.nature.com/articles/s43586-021-00021-6
https://www.sciencedirect.com/science/article/pii/S0092867418315113
Image Sources:
https://www.istockphoto.com/photo/three-tweezers-tweezers-on-a-white-background-gm1262858821-369561418
https://www.storyblocks.com/video/stock/a-young-man-plucking-his-eyebrows-with-tweezers-styling-eyebrows-macro-r05jp9o1fja32nmvz
https://www.storyblocks.com/video/stock/seamless-looping-animation-of-rotating-dna-strands-e1hwm_0cgiks0m37h
https://commons.wikimedia.org/wiki/File:Nucleosome_1KX5_2.png
https://www.storyblocks.com/video/stock/animation-of-genetic-dna-loop-able-4k-rxfbx2wcgizuoo76d
https://www.storyblocks.com/video/stock/floating-cells-multiplying-red-version-lxo-vwt
https://www.istockphoto.com/photo/chromosome-isolated-on-white-background-with-depth-of-field-effect-gm584244506-100036213
https://commons.wikimedia.org/wiki/File:Nucleosome_organization.png
https://commons.wikimedia.org/wiki/File:Nucleosome.png
https://commons.wikimedia.org/wiki/File:Basic_units_of_chromatin_structure.svg
https://commons.wikimedia.org/wiki/File:Sail-Force1.gif
https://commons.wikimedia.org/wiki/File:World%27s_first_laser_out_of_case.jpg
https://commons.wikimedia.org/wiki/File:Military_laser_experiment.jpg
https://commons.wikimedia.org/wiki/File:Femtomolar_Optical_Tweezers_(5881942888).jpg
https://www.istockphoto.com/photo/chromatin-strand-and-isolated-nucleosome-dna-histones-gm1169905740-323575931
https://commons.wikimedia.org/wiki/File:1aoi_nucleosome_rib_round.tif
https://commons.wikimedia.org/wiki/File:Stylized_DNA.png
https://www.storyblocks.com/video/stock/lamp-and-the-books-in-library-2-rag585s9rk2i80i6s
https://commons.wikimedia.org/wiki/File:Table_chamber_GWMorley.jpg
https://www.istockphoto.com/photo/3d-illustration-protein-or-enzyme-gm1138925640-304251159
https://www.storyblocks.com/video/stock/dna-sequencing-the-bases-of-a-fragment-of-dna-abstract-background-skx-uxydpkgvmnshp
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